However, doxycycline-dependent SK3 null mutant mice exhibited increased extracellular striatal dopamine, enhanced hippocampal serotonin release, and reduced hippocampal brain-derived neurotrophic factor BDNF expression. Properties To Rent in SK3. Simply select from the local agents listed, provide your details and the agents will be in touch to book an appointment for your free, no-obligation market appraisal. A polyglutamine repeat in a calcium-activated potassium channel, SK3, which is important for synaptic plasticity, has been discussed for some time as potential risk factor for schizophrenia. Double glazed, gas central heating, well presented and decorated throughout.

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Matching molecules to function: KCNN3encoding the small conductance calcium-activated potassium channel SK3, harbours a polymorphic CAG repeat in the amino-terminal coding region with yet unproven function. Brain Ssk3 Mol Brain Res. Commercial New Home Development Microsite. Both models show consistently that higher sums of CAG repeats are associated with higher sk better performance in the cognitive target but not the cognitive control variables including premorbid intelligence, representing the development-dependent intellectual state at disease onset.

All measurements were performed by a blinded investigator.

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Even though the functional significance of a variable glutamine repeat length in the SK3 channel protein has remained unclear, it sk33 been investigated in the context of certain pathologies in humans. This article has been cited by other articles in PMC.


Such documents are peer-reviewed, but not copy-edited or typeset. We use cookies to optimise your experience on our website. Parking is available on site.

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This material was last updated on 29 March On the contrary, SK3 overexpression in mice, as a model of increased channel function, leads to reduced cognitive abilities in a similar set of tasks. The distribution of allelic repeat lengths sum and allelic repeat lengths difference in the schizophrenic population is displayed in Table S1.

To test this hypothesis, we analysed basic behaviour and cognition in a transgenic mouse line in which the murine SK3 gene is overexpressed under control of its own regulatory elements, enhanced in cis by the wk3 transactivator tTA in the absence of any doxycyclin Bond et al, The nine exons boxes encode two different splicing variants 1, so3 ; the coding region is shaded in grey. In contrast, family-based studies claimed a connection between shorter CAG repeats and schizophrenia Stober et al, Views Read Edit View history.

Even if traits of interest in schizophrenia here: KCNN3 is located at 1q With all Furnishings, bills, garde Indicated are locations of the CAG repeat labelled in orangeof the primers labelled in purple and of the restriction enzyme sites used for cloning. Statistical significance was evaluated using unpaired Student’s t -test and two-way repeated measurement ANOVA including Bonferroni testing where applicable.


Pharmacological modulation of SK3 channels.

All phenotypes were standardized to zero mean and variance one: Association between anorexia nervosa and the hsKCa3 gene: Located on a sought after road in Cheadle Heath is this attractive four double bedroom period family home situated on an elevated corner plot with extensive gardens sj3 a detached tandem garage. Data on cognitive tests are presented in a way that higher values always indicate better performance. Length variation of a polyglutamine array in the gene encoding a small-conductance, calcium-activated potassium channel hKCa3 and susceptibility to idiopathic generalized epilepsy.

The block has its own car parking area, with enough parking allocated for each flat.

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Open in a separate window. A lovely, bright, recently refurbished two double bedroom semi-detached house to rent in the heart of Edgeley.

LAP conducted the electrophysiology. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Internally the property is bright, spacious and in brief comprises of; Lounge to front sk33 bay window, dining room, kitchen, utility room and downstairs WC.